Researchers Use SLAC鈥檚 Synchrotron to Monitor How One Protein鈥檚 Evolution Could Affect Transmission of Avian Flu to and Between Humans
SLAC National Accelerator LaboratorySince the first recorded case of highly pathogenic avian influenza H5N1 鈥 commonly known as avian flu or bird flu 鈥 in 1996, Ian Wilson, professor of structural biology at Scripps Research, and his colleagues have been closely tracking the evolution of several key proteins using SSRL. Recently, Wilson鈥檚 team investigated the evolution of a protein that plays a crucial role in H5N1鈥檚 ability to transmit between species. Their analysis found that the protein is susceptible to a mutation that could help the virus attach to human cells, potentially increasing the risk of human transmission. The findings 鈥 published in Proceedings of the National Academy of Sciences 鈥 underscore the need for ongoing monitoring of H5N1鈥檚 evolution.